NET models meeting 2024: the current state of neuroendocrine tumour research models and our future aspirations

in Endocrine Oncology
Authors:
Po Hien Ear P Ear, Surgery, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, 52242, United States

Search for other papers by Po Hien Ear in
Current site
Google Scholar
PubMed Close
,
Ilaria Marinoni I Marinoni, Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland

Search for other papers by Ilaria Marinoni in
Current site
Google Scholar
PubMed Close
,
Talya Dayton T Dayton, EMBL Barcelona, Barcelona, 08003, Spain

Search for other papers by Talya Dayton in
Current site
Google Scholar
PubMed Close
,
Rachael Guenter R Guenter, Surgery, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, 35233, United States

Search for other papers by Rachael Guenter in
Current site
Google Scholar
PubMed Close
,
Dawn Quelle D Quelle, Department of Neuroscience and Pharmacology, The University of Iowa, Iowa City, United States

Search for other papers by Dawn Quelle in
Current site
Google Scholar
PubMed Close
,
Anna Battistella A Battistella, Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, Istituto Scientifico Universitario San Raffaele, Milano, Italy

Search for other papers by Anna Battistella in
Current site
Google Scholar
PubMed Close
,
Floryne O Buishand F Buishand, Department of Clinical Science and Services, Royal Veterinary College, London, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Floryne O Buishand in
Current site
Google Scholar
PubMed Close
,
Suganthi Chittaranjan S Chittaranjan, Department of Genome Sciences centre, BC Cancer - Vancouver, Vancouver, Canada

Search for other papers by Suganthi Chittaranjan in
Current site
Google Scholar
PubMed Close
,
Yi-Cheih Nancy Du Y Du, Pathology and Laboratory Medicine, Cornell University Joan and Sanford I Weill Medical College, New York, United States

Search for other papers by Yi-Cheih Nancy Du in
Current site
Google Scholar
PubMed Close
,
Ines Marques I Marques, Institute of Anatomy, University of Bern, Bern, Switzerland

Search for other papers by Ines Marques in
Current site
Google Scholar
PubMed Close
,
Natalia Pellegata N Pellegata, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

Search for other papers by Natalia Pellegata in
Current site
Google Scholar
PubMed Close
,
Samira Mercedes Sadowski S Sadowski, Surgical Oncology Program, CCR, NCI, National Institutes of Health, Bethesda, 20892, United States

Search for other papers by Samira Mercedes Sadowski in
Current site
Google Scholar
PubMed Close
,
Amit Tirosh A Tirosh, NET Unit, Sheba Medical Center, Tel Hashomer, 5262100, Israel

Search for other papers by Amit Tirosh in
Current site
Google Scholar
PubMed Close
,
Simon April-Monn S April-Monn, Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland

Search for other papers by Simon April-Monn in
Current site
Google Scholar
PubMed Close
,
Cinzia Aurilia C Aurilia, Associazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Italy, Italy

Search for other papers by Cinzia Aurilia in
Current site
Google Scholar
PubMed Close
,
Renata Jaskula-Sztul R Jaskula-Sztul, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, United States

Search for other papers by Renata Jaskula-Sztul in
Current site
Google Scholar
PubMed Close
,
Maria Jesús Baena Moreno M Baena Moreno, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Maria Jesús Baena Moreno in
Current site
Google Scholar
PubMed Close
,
Simone Donati S Donati , Associazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Italy, Italy

Search for other papers by Simone Donati in
Current site
Google Scholar
PubMed Close
,
Katherine A English K English, Academic Endocrine Unit, University of Oxford, Oxford, OX3 7LE, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Katherine A English in
Current site
Google Scholar
PubMed Close
,
Maria A. Hernandez Llorens M Hernandez Llorens, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Maria A. Hernandez Llorens in
Current site
Google Scholar
PubMed Close
,
Harry Hodgetts H Hodgetts, University College London, London, WC1E 6BT, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Harry Hodgetts in
Current site
Google Scholar
PubMed Close
,
Francesca Marini F Marini, FIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, Italy

Search for other papers by Francesca Marini in
Current site
Google Scholar
PubMed Close
,
Maria Martins M Martins, University College London, London, WC1E 6BT, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Maria Martins in
Current site
Google Scholar
PubMed Close
,
Gaia Palmini G Palmini, FIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, Italy, Italy

Search for other papers by Gaia Palmini in
Current site
Google Scholar
PubMed Close
,
Beatriz Soldevilla B Soldevilla, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Beatriz Soldevilla in
Current site
Google Scholar
PubMed Close
,
Jörg Schrader J Schrader, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Search for other papers by Jörg Schrader in
Current site
Google Scholar
PubMed Close
,
Rajesh V Thakker R Thakker, OCDEM, Radcliffe Department of Medicine, UNIVERSITY OF OXFORD, OXFORD, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Rajesh V Thakker in
Current site
Google Scholar
PubMed Close
, and
Kate E Lines K Lines, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, United Kingdom of Great Britain and Northern Ireland

Search for other papers by Kate E Lines in
Current site
Google Scholar
PubMed Close

Correspondence: Kate Lines, Email: klines@brookes.ac.uk
DOI:
https://doi.org/10.1530/EO-24-0055
Volume/Issue:
Accepted Manuscripts
Article Type:
Review Article
Article ID:
EO-24-0055
Online Publication Date:
01 Nov 2024
Copyright:
© 2024 The authors 2024
Open access

Sign up for journal news

Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids), and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET Models meeting, hosted by our founding group: Dr. Lines (Oxford); Prof. Quelle (Iowa); Dr. Dayton (Barcelona); Dr. Ear (Iowa); Dr. Marinoni (Bern); and Dr. Guenter (Alabama). This 2-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by 30 international researchers (from UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker who summarised NET research over the last few decades, and Dr. Schrader who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting, to zebrafish models, and included novel ideas as well as improvements on current concepts. This was followed by an interactive workshop where discussion topics included, a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions, as well as the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025, contact contact@netcancerfoundation.com for more information.

Endocrine Oncology is committed to supporting researchers in demonstrating the impact of their articles published in the journal.

As an open-access journal, Endocrine Oncology articles are immediately available to read on publication, without restriction. The two types of article metrics we measure are (i) more traditional full-text views and pdf downloads, and (ii) Altmetric data, which shows the wider impact of articles in a range of non-traditional sources, such as social media.

More information is on the Reasons to publish page.

Feb 2021 onwards Past Year Past 30 Days
Full Text Views 174 174 174
PDF Downloads 126 126 126

 

  • Collapse
  • Expand
Online ISSN:
2634-4793
Copyright:
© 2024 The authors 2024
Article ID:
EO-24-0055
Article Type:
Review Article
Received Date:
10 Sep 2024
Rev-recd:
12 Nov 2024
Accepted Date:
19 Nov 2024
Online Publication Date:
01 Nov 2024