NET models meeting 2024: the current state of neuroendocrine tumour research models and our future aspirations

in Endocrine Oncology
Authors:
Po Hien Ear P Ear, Surgery, The University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, 52242, United States

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Ilaria Marinoni I Marinoni, Institute of Tissue Medicine and Pathology, University of Bern, Bern, Switzerland

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Talya Dayton T Dayton, EMBL Barcelona, Barcelona, 08003, Spain

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Rachael Guenter R Guenter, Surgery, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, 35233, United States

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Dawn Quelle D Quelle, Department of Neuroscience and Pharmacology, The University of Iowa, Iowa City, United States

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Anna Battistella A Battistella, Pancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, Istituto Scientifico Universitario San Raffaele, Milano, Italy

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Floryne O Buishand F Buishand, Department of Clinical Science and Services, Royal Veterinary College, London, United Kingdom of Great Britain and Northern Ireland

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Suganthi Chittaranjan S Chittaranjan, Department of Genome Sciences centre, BC Cancer - Vancouver, Vancouver, Canada

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Yi-Cheih Nancy Du Y Du, Pathology and Laboratory Medicine, Cornell University Joan and Sanford I Weill Medical College, New York, United States

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Ines Marques I Marques, Institute of Anatomy, University of Bern, Bern, Switzerland

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Natalia Pellegata N Pellegata, Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

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Samira Mercedes Sadowski S Sadowski, Surgical Oncology Program, CCR, NCI, National Institutes of Health, Bethesda, 20892, United States

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Amit Tirosh A Tirosh, NET Unit, Sheba Medical Center, Tel Hashomer, 5262100, Israel

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Simon April-Monn S April-Monn, Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland

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Cinzia Aurilia C Aurilia, Associazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Italy, Italy

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Renata Jaskula-Sztul R Jaskula-Sztul, The University of Alabama at Birmingham Heersink School of Medicine, Birmingham, United States

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Maria Jesús Baena Moreno M Baena Moreno, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

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Simone Donati S Donati , Associazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Italy, Italy

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Katherine A English K English, Academic Endocrine Unit, University of Oxford, Oxford, OX3 7LE, United Kingdom of Great Britain and Northern Ireland

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Maria A. Hernandez Llorens M Hernandez Llorens, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

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Harry Hodgetts H Hodgetts, University College London, London, WC1E 6BT, United Kingdom of Great Britain and Northern Ireland

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Francesca Marini F Marini, FIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, Italy

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Maria Martins M Martins, University College London, London, WC1E 6BT, United Kingdom of Great Britain and Northern Ireland

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Gaia Palmini G Palmini, FIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, Italy, Italy

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Beatriz Soldevilla B Soldevilla, Center of Experimental Oncology. Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, Spain, United Kingdom of Great Britain and Northern Ireland

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Jörg Schrader J Schrader, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

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Rajesh V Thakker R Thakker, OCDEM, Radcliffe Department of Medicine, UNIVERSITY OF OXFORD, OXFORD, United Kingdom of Great Britain and Northern Ireland

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Kate E Lines K Lines, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, United Kingdom of Great Britain and Northern Ireland

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Correspondence: Kate Lines, Email: klines@brookes.ac.uk
DOI:
https://doi.org/10.1530/EO-24-0055
Volume/Issue:
Accepted Manuscripts
Article Type:
Review Article
Article ID:
EO-24-0055
Online Publication Date:
01 Nov 2024
Copyright:
© 2024 The authors 2024
Open access

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Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids), and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET Models meeting, hosted by our founding group: Dr. Lines (Oxford); Prof. Quelle (Iowa); Dr. Dayton (Barcelona); Dr. Ear (Iowa); Dr. Marinoni (Bern); and Dr. Guenter (Alabama). This 2-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by 30 international researchers (from UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker who summarised NET research over the last few decades, and Dr. Schrader who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting, to zebrafish models, and included novel ideas as well as improvements on current concepts. This was followed by an interactive workshop where discussion topics included, a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions, as well as the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025, contact contact@netcancerfoundation.com for more information.

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Online ISSN:
2634-4793
Copyright:
© 2024 The authors 2024
Article ID:
EO-24-0055
Article Type:
Review Article
Received Date:
10 Sep 2024
Rev-recd:
12 Nov 2024
Accepted Date:
19 Nov 2024
Online Publication Date:
01 Nov 2024