Paragangliomas of the head and neck: a contemporary review

in Endocrine Oncology
Authors:
Nathan J Graham Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

Search for other papers by Nathan J Graham in
Current site
Google Scholar
PubMed
Close
https://orcid.org/0000-0002-2648-4838
,
Joshua D Smith Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

Search for other papers by Joshua D Smith in
Current site
Google Scholar
PubMed
Close
,
Tobias Else Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA

Search for other papers by Tobias Else in
Current site
Google Scholar
PubMed
Close
, and
Gregory J Basura Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

Search for other papers by Gregory J Basura in
Current site
Google Scholar
PubMed
Close

Correspondence should be addressed to T Else: telse@med.umich.edu
Open access

Sign up for journal news

Head and neck paragangliomas (HNPGLs) are slow-growing, vascular, typically benign tumors whose growth may induce significant lower cranial nerve deficits. While most tumors arise sporadically, a significant portion is associated with defined genetic syndromes. While surgical resection has historically been the gold standard, management strategies have evolved with acknowledgement of high surgical morbidity, slow tumor growth rates, and technological advances. Conservative management approaches via observation and newer radiation therapy techniques have become more common. This review seeks to provide an update on contemporary management strategies for HNPGLs and future directions.

Abstract

Head and neck paragangliomas (HNPGLs) are slow-growing, vascular, typically benign tumors whose growth may induce significant lower cranial nerve deficits. While most tumors arise sporadically, a significant portion is associated with defined genetic syndromes. While surgical resection has historically been the gold standard, management strategies have evolved with acknowledgement of high surgical morbidity, slow tumor growth rates, and technological advances. Conservative management approaches via observation and newer radiation therapy techniques have become more common. This review seeks to provide an update on contemporary management strategies for HNPGLs and future directions.

Introduction

Head and neck paragangliomas (HNPGLs) are rare, slow-growing, vascular tumors arising from cells associated with autonomous ganglia (paraganglial cells) in the head and neck, 95% of which are non-secretory (Fig. 1). Evidence is growing that most paragangliomas (PGLs) are associated with hereditary syndromes in >50% of patients (Horton et al. 2022, Richter et al. 2022). The most common inherited syndrome involves germline pathogenic variants in genes encoding succinate dehydrogenase (SDH) complex subunits. SDH loss promotes cell proliferation, angiogenesis, and tumorigenesis (Gottlieb & Tomlinson 2005). Sporadic tumors are typically solitary, unilateral, and arise between 40 and 70 years of age, while hereditary tumors are more likely multiple and metastatic, and present at younger age (Ikram & Rehman 2022).

PGL subtypes may be categorized by anatomic subsite as either cervical or involving the temporal bone. Cervical PGLs consist predominantly of carotid body tumor paragangliomas (CBTs), glomus vagale paragangliomas (GVs), and, less commonly, cervical sympathetic chain PGLs. CBTs are most common, typically benign, and arise from the carotid body (Offergeld et al. 2012). They are often found incidentally on imaging studies or as a painless, palpable, and possibly pulsatile neck mass near the jaw angle. Possible symptoms include hoarseness, dysphagia, and/or autonomic dysfunction due to encroachment of nearby cranial nerves (CNs) IX (glossopharyngeal) and X (vagus). GVs arise along CN X, most commonly from the inferior ganglion. They typically present as an asymptomatic high neck mass but may also present with pulsatile tinnitus and CN IX, X, XI (spinal accessory), and/or XII (hypoglossal) deficits (Offergeld et al. 2012 Prasad et al. 2019).

Temporal bone PGLs arise from the jugular bulb near the skull base as glomus jugulare paragangliomas (GJs) or in the middle ear cavity as glomus tympanicum paragangliomas (GTs). They most often present with pulsatile tinnitus and/or conductive hearing loss (Carlson et al. 2015). Less common symptoms include dysphonia, shoulder weakness/pain, dysarthria, and facial paralysis, all of which should raise greater suspicion for GJs vs GTs (Moore et al. 2016). GTs classically present as a red mass behind the tympanic membrane with blanching on pneumatic otoscopy (Sweeney et al. 2015).

As mentioned, sympathetic chain PGLs are exceedingly rare but may be considered during diagnostic approach for parapharyngeal masses. Common presenting signs include ipsilateral Horner syndrome (partial ptosis, miosis, and anhidrosis) and oropharyngeal fullness. Sympathetic chain PGLs more commonly secrete catecholamines compared to other PGLs, though all HNPGLs may potentially possess this feature (Seth et al. 2014). Other exceedingly rare HNPGL subsites include laryngeal PGLs, arising from the supraglottic or subglottic larynx and presenting with dysphonia or airway obstruction (Myssiorek et al. 2004), and parotid gland PGLs (Vora et al. 2012).

Figure 1
Figure 1

HNPGL subsites. Figure 1 was drawn based on images from Harrison (2009) and Gaillard (2015).

Citation: Endocrine Oncology 2, 1; 10.1530/EO-22-0080

Figure 3
Figure 3

Intraoperative transmastoid approach of glomus jugulare invading up and through the skull base, the middle ear, through the ear canal, and eroding CN VII. The tumor was debulked prior to cable-grafting CN VII and over-closing the ear canal to prevent cholesteatoma.

Citation: Endocrine Oncology 2, 1; 10.1530/EO-22-0080

Classification

Various classification systems have been proposed for PGLs to improve physician communication and guide operative decision-making. The Shamblin system classified CBTs based on intraoperative anatomical and histopathological findings of tumor size and involvement of the internal carotid artery (ICA) or external carotid artery (ECA). Group 1 tumors are smaller and easily resectable without damage to nearby structures, while Group 2 tumors are larger with greater ICA involvement. Group 3 tumors adhere more to the carotid artery, and its sacrifice is often required during tumor resection (Shamblin et al. 1971); (Table 1). However, the Shamblin system is limited by its retrospective nature and inability to guide management, though some use it to predict vascular morbidity (Prasad et al. 2019).Arya et al. (2008) proposed a modified Shamblin system based on radiographic evidence of carotid artery involvement without consideration of tumor size to determine resectability and guide preoperative decision-making (Fig. 2A-C). No widely accepted classification system exists for GVs (Offergeld et al. 2012).

Figure 2
Figure 2

Axial post-contrast MRI findings for Shamblin class I CBT (A), class II CBT (B), and class III CBT (C).

Citation: Endocrine Oncology 2, 1; 10.1530/EO-22-0080

Table 1

Shamblin classification for CBTs.

Class Tumor characteristics
I Smaller tumors, sparse carotid vessel involvement; completely resectable with minimal morbidity
II Larger tumors, involvement with or possible infiltration of external and internal carotid arteries; complete resection challenging but possible, likely with greater risk of morbidity
III Large tumors adherent to and surrounding carotid arteries; complete resection almost always requires vessel sacrifice and reconstruction

The Fisch classification has historically guided surgical approach and resectability of GJs and GTs. Class A tumors are confined to the promontory, class B tumors invade the hypotympanon, class C tumors are subdivided based on the extent of bone erosion into nearby structures, while class D tumors extend intracranially (Table 2).

Table 2

Fisch classification for GJs.

Class Paraganglioma location
A Tumor arises on promontory
B Tumor with invasion of hypotympanon; cortical bone over jugular bulb intact
C Tumor with invasion beyond typanomastoid cavity with destruction of infralabyrinthine and apical temporal bone
 C1 Tumor with erosion of carotid foramen
 C2 Tumor with destruction of carotid canal
 C3 Tumor with invasion of the horizontal part of carotid canal; foramen lacerum intact
 C4 Tumor with invasion of foramen lacerum and cavernous sinus
D Tumor invades intracranially
 D1 Tumor with intracranial but extradural extension
 D2 Tumor with intracranial and intradural extension

While similar in name and histological structure, HNPGLs differ from thoracoabdominal paragangliomas and pheochromocytomas (PPGLs) by more than location. HNPGLs are typically nonchromaffin, nonfunctional, parasympathetic tumors, while thoracoabdominal PPGLs are often chromaffin and catecholamine-secreting sympathetic tumors (Kimura et al. 2021) (Fig. 2).

Several HNPGL treatment options exist. Previously, surgery was considered first-line management; however, high morbidity rates associated with aggressive resection prompted many to favor conservative measures. As knowledge grows regarding how tumor genetics impact prognosis and treatment response, aggressive treatment may become more patient specific. This review focuses on recent reports regarding HNPGL management strategies, including growth rate surveillance, surgical approaches, and radiation therapy.

Observation/natural history

The general approach to any HNPGL is weighing the risks of surgery, perioperative complications, and irreversible postsurgical sequelae, such as CN deficits, against quality of life (QoL) limitations from the tumor itself. One must also consider metastatic potential – while overall low in HNPGL, it reduces life expectancy, and with progression of disease, it can significantly impact QoL.

CBTs are typically slow growing, with a reported median growth rate of 1.6 mm/year. While CBT growth increases with time, the probability of tumor growth decreases with increased age at diagnosis and higher tumor volume. Observation, therefore, may be indicated for small, benign, asymptomatic tumors, elderly patients, and/or those with surgical comorbidities (Heesterman et al. 2017). Nevertheless, for patients ≥60 years old and with minimal comorbidities, surgery remains a viable option at high-volume head and neck cancer centers, with outcomes comparable to patients of younger age (Li et al. 2021). The median time to growth is reportedly 1.5 years; surgery may therefore be delayed even in younger patients, if asymptomatic (Heesterman et al. 2017). However, observation increases the risk of developing new or worsening symptoms, skull base invasion, carotid artery invasion, and postoperative complications; intervention should occur before such symptoms develop or worsen.

Serial observation is preferred for GVs due to their slow median growth rate of 1.6 mm/year, which is similar to CBTs and greater than temporal PGLs (Jansen et al. 2017). Surgery almost always requires CN X sacrifice; resection is thus recommended only after lower CN deficits develop or if the tumor is metastatic or catecholamine secreting, which can be managed with preoperative α-antagonists and β-blockers to avoid hypertensive crisis but cannot be medically managed alone (Shin et al. 2012). Observation is often preferred in elderly populations due to slow tumor growth, comorbidities, and greater difficulty with swallowing rehabilitation after high vagal sacrifice (Netterville et al. 1998). Observation is also preferred in patients with prior contralateral CN X or XII palsy due to the high risk of ipsilateral CN damage during resection (Shin et al. 2012). Surgical resection in bilateral GVs also confers the risk of bilateral lower CN damage; observation is thus preferred until growth is observed, at which point external beam radiotherapy (EBRT) or stereotactic radiosurgery (SRS) may be indicated (Netterville et al. 1998).

GJ diagnosis is typically delayed due to its low prevalence, difficult-to-examine location, and slow growth rate (Carlson et al. 2015). Once diagnosed, symptoms have often been present for months. GJs are typically benign and have a slow median growth rate of 0.8 mm/year, making observation a preferred management strategy (Carlson et al. 2015). Observation may be limited by worsening or new-onset CN deficits (Moore et al. 2016). In a case series of 15 GJ patients on observation with a median follow-up of 86.4 months, hearing loss worsened in 38%, pulsatile tinnitus worsened in 0%, CN X function was preserved in 50%, and 69% had normal CN XI and XII function. Under a third of patients had new or worsening lower CN deficits (Carlson et al. 2015). Nevertheless, aggressive GJ resection is associated with significant risk of permanent CN IX, X, XI, and XII damage and possibly CN VII paralysis. When indicated, treatment with RT is often recommended to slow tumor growth (van Hulsteijn et al. 2013).

While observation is an option, GTs are typically managed surgically. Endoscopic examination and/or serial examinations may be used if patients elect for observation over definitive treatment (Killeen et al. 2017). While observation is not widely described in the literature, this strategy likely increases risks of cranial neuropathy and invasive disease.

Surgical management

When tumor growth or new/worsening symptoms arise, more aggressive measures with surgery may be indicated. Other management options include observation or radiation therapy, while medical oncological therapy is usually reserved for metastatic disease. If a tumor is functional, perioperative α-adrenergic and possibly β-adrenergic blockade might be necessary.

Patients with GJs, GVs, and CBTs may benefit from preoperative embolization (POE) due to the tumors’ highly vascular nature. The nearby ICA and ECA make these tumors easy targets. POE may reduce intraoperative blood loss, operative times, and complications. However, embolization poses a risk for stroke, cranial neuropathies, and vagal or sympathetic chain damage. Although reports of brain embolisms or paradoxical embolisms through PFOs are rare, they are a real risk and embolization should be considered carefully (Griauzde et al. 2013).

Reports are conflicting regarding POE efficacy for HNPGLs. Previous studies reported reduced intraoperative blood loss, shorter operative time, and lower complication rates for POE in patients with CBTs and other HNPGLs (Antonitsis et al. 2006, Gupta et al. 2007, Li et al. 2010). However, a recent meta-analysis of 470 patients with CBTs found no significant differences in blood loss, operative time, hospital time, or complications between embolization and non-embolization groups (Abu-Ghanem et al. 2016). Failure to completely occlude tumor feeding vessels may increase the risk of revascularization postoperatively; in one report, three such GJ patients had no long-term clinical improvement (Kocur et al. 2017). Helal et al. (2022) reported that 86% of GJ patients had a >50% tumor blush reduction and zero patients had new or worsened lower CN deficits following POE. Another study reported less perioperative bleeding but a greater CN paresis in GJ patients post-POE (Yildiz et al. 2021).Katagiri et al. (2019) reported a tumor size reduction of 50% with only transient lower CN deficits in a series of 13 CBT patients. Only one study has compared POE to surgery alone in HNPGLs, in which POE was associated with lower intraoperative blood loss, transfusion requirements, complication rates, and surgical time (Liu et al. 2018).

There are various embolization materials, but no randomized trials exist comparing different materials in patients with HNPGLs. In terms of embolization approach, no studies yet have demonstrated superior devascularization with percutaneous, endovascular, or combined approaches (De Marini et al. 2021).

Nonetheless, POE appears to be a relatively safe and effective strategy for select HNPGLs. Patients should be selected carefully based on tumor size (>3 cm in diameter), high vascularization, and absence of preexisting lower CN deficits (Colli et al. 2021). Alternatively, Jang et al. (2018) described a sigmoid sinus tunnel-packing technique in GJ resections that controlled inferior petrous sinus bleeding and improved outcomes with lower costs than POE.

Surgical goals

Cervical PGLs

Gross total resection (GTR) is the gold standard for resectable CBTs in healthy patients due to risks of damage to local structures and risk of metastatic disease if left untreated (Burgess et al. 2017). Complete tumor regression with RT or chemotherapy alone is rare (Mendenhall et al. 2001). Common complications of CBT resection include ECA ligation, CN XII paralysis, and carotid artery blowout (Fathalla & Elalfy 2020). CN neuropathy risk is highest in tumors >5 cm and/or Shamblin class III tumors due to carotid artery encasement (Arya et al. 2008).

Patients with GVs typically present only after symptoms arise, at which point observation usually is no longer indicated. Tumor resection extent then depends on several factors, most importantly age and health status. For elderly but otherwise healthy patients, incomplete resection with lower CN preservation or GTR with vocal cord medialization may be considered (Shin et al. 2012). For younger patients, GTR is typically recommended due to their relatively greater tolerance to lower CN deficits, greater response to rehabilitation, and greater risk of recurrence over time from residual tumor (Prasad et al. 2019). Unfortunately, CN X is almost always sacrificed during GV resection. In addition to dysphonia and dysphagia, GV resection is associated with ipsilateral pharynx numbness, velopharyngeal insufficiency, CN XII deficits, persistent shoulder pain/weakness, persistent nausea/vomiting, and baroreceptor dysfunction (Moore et al. 2016) (Table 3).

Table 3

CN involvement by common HNPGL subtypes. The most common findings are bolded.

Tumor type CN involvement Possible presenting symptoms CNs almost always resected/injured
CBP IX, X, XI, XII Painless lateral neck mass. Hoarseness, dysphagia, vertigo, Horner syndrome Rarely X or XII
VP VIII, IX, X, XI, XII Asymptomatic neck mass behind mandible. Pulsatile tinnitus, hearing loss, dysphagia, shoulder drop, hemiatrophy of tongue X > XII
JFP VII, VIII, X, XI, XII Facial paralysis, pulsatile tinnitus, conductive hearing loss, aural fullness, sensorineural hearing loss and/or dizziness (inner ear invasion), dysphonia/hoarseness, dysphagia/aspiration, shoulder weakness/pain, tongue paralysis IX > X, XI > XII
TP VIII Pulsatile tinnitus, conductive hearing loss, aural fullness Rarely VIII

Typically, a transcervical approach is used for cervical PGLs (Fathalla & Elalfy 2020). Transcervical–transparotid approaches may be helpful for tumors extending into the middle parapharyngeal space (PPS), transcervical–transmastoid approaches for those extending into the upper PPS (Fig. 3), and infratemporal fossa approaches for upper PPS tumors extending to the vertical tract of the ICA and jugular bulb (Shin et al. 2012, Prasad et al. 2019).

Temporal PGLs

Traditionally, GJs have been managed with GTR, which yielded high tumor control rates but high morbidity due to their location along the lateral skull base, proximity to lower CNs, local invasiveness, and high vascularity (Gandía-González et al. 2014). Postoperatively, patients often experience conductive hearing loss, facial palsy, and lower CN deficits (Bacciu et al. 2015). Subtotal resection (STR) strategies have become popularized due to reduced risks of lower CN deficits (Miller et al. 2009). STR is often used in conjunction with salvage or adjuvant SRS in instances of residual tumor growth or recurrence (Jansen et al. 2018). Several studies have demonstrated lower rates of new-onset lower CN deficits with STR compared to GTR (Manzoor et al. 2021). Resection extent in STR varies by disease extent and patient preferences; high-volume tumors extending into cervical and infratemporal fossa locations may require extended STR. Tumor invasion into the middle ear and mastoid or intracranially may prompt limited STR. Limited STR strategies are often performed to limit tinnitus and improve hearing loss by targeted tumor removal. Evidence suggests no relationship between new-onset CN deficits and STR approach (Manzoor et al. 2021).

Several surgical approaches for GJs have been described. Historically, translabyrinthine/transcochlear approaches were used but yielded ipsilateral hearing loss (Walker & Babu 2019). Later, infratemporal fossa approach type A became the standard approach for larger tumors due to greater surgical exposure, though this approach still often left patients with a maximal conductive hearing loss (Walker & Babu 2019). For tumors extending intracranially, lateral and posterolateral skull base approaches are helpful while transcranial endoscopic approaches or tympanomastoidectomy may be employed in patients with limited middle ear disease (Manzoor et al. 2021). Preoperative imaging should be utilized to determine the best approach for each patient based on tumor size, extent, and patient characteristics.

GTs have traditionally been surgically managed via transcanal and/or postauricular microscope-based approaches, with the latter used predominantly for larger tumors. Evidence has emerged suggesting safe and efficacious GT management via transcanal endoscopic approaches (TEA) for tumors without mastoid bone extension. Fermi et al. (2021) reported a 90% GTR rate with few complications and favorable hearing outcomes using TEA. GTR was unachievable in 10% of patients due to tumor extension to the ICA and concern for severe bleeding; however, all patients experienced symptom resolution with no evidence of recurrence during a mean follow-up of 24.3 months. Because morbidity and mortality are limited in surgically managed GTs, radiotherapy (RT) is thought to pose greater risk than benefit (Fermi et al. 2021).

Radiation therapy

Goals of radiation

RT has previously been viewed as an adjunct to surgical resection except in select patient populations. For poor surgical candidates, recurrent disease, unresectable locations, and/or palliation, RT can slow tumor growth and reduce the need for surgery (Jackson et al. 2001). RT may be reserved for patients with tumor growth on serial imaging due to its serious adverse effects: osteoradionecrosis, secondary malignancy, and vascular ischemic events (Lassen-Ramshad et al. 2019). However, in recent years, indications for RT over surgery have grown as newer technology has lowered RT-associated morbidity, while surgical morbidity has gained greater recognition.

Conventional external beam radiation therapy vs stereotactic radiosurgery

Different RT techniques have been developed over the years. Previously, conventional EBRT was most commonly used, but has been associated with greater late toxicity rates than newer stereotactic RT (Lassen-Ramshad et al. 2019). With technological advances and a movement toward less-invasive HNPGL management, SRS has gained favor, specifically in GJs as it is faster, more convenient, and highly precise and reduces risk of morbidity and lower CN deficits compared to GTR (Lieberson et al. 2012, van Hulsteijn et al. 2013). As opposed to conventional EBRT where patients receive targeted treatments over weeks, SRS utilizes 3D imaging to deliver single, high-dose, highly precise radiation, limiting collateral damage to nearby healthy tissues. A recent meta-analysis of 1117 HNPGL patients revealed a local control rate of 94.2% after adjuvant or primary SRS (Fatima et al. 2021). Pooled estimates of 5-year and 10-year local control was also favorable at 96% and 93.4%, respectively. Clinical neurological symptoms improved in 48.7% of patients, had no change in 39.3%, and worsened in 1.2%. While primary SRS was negatively correlated with lower chances of radiographic local control, one study reported greater correlation with morbidity in surgery than primary RT/SRS and a 78% greater probability of local control than surgery alone (Fatima et al. 2021). These studies were limited by relatively short follow-up periods (median 44 months); patients may experience additional morbidity during long-term follow-up. Early SRS adverse effects include transient or permanent lower CN neuropathies, headache, nausea/vomiting, and facial spasm. Importantly, primary SRS does not allow for tissue diagnosis, allowing possible aggressive neoplasms to go undiagnosed (Miller et al. 2009).

Other EBRT subtypes have been developed, including intensity modulated radiation therapy (IMRT) and intensity modulated proton therapy (IMPT), which have lower morbidity for at-risk nearby structures. IMPT also spares healthy tissues and further limits adverse effects (Nguyen et al. 2021). Compared to IMRT, IMPT adequately covers clinical target volume while offering dosimetric advantages, which theoretically lowers the risk of RT-related morbidity (Nguyen et al. 2021). IMRT has been demonstrated as highly efficacious in HNPGLs while limiting morbidity (Anderson et al. 2020). Few studies have investigated IMPT efficacy specifically in HNPGLs.

Special populations

Genetic predisposition

There is a strong association between HNPGL and hereditary predisposition to HNPGLs. The most common inherited condition – hereditary PGL syndrome – is caused by a pathogenic variant in one of the genes encoding the subunits of SDH (SDHA, SDHB, SDHC, SDHD,and SDHAF2). Patients with pathogenic variants in SDHD are especially prone to developing HNPGLs, which are often multiple. Overall, a germline pathogenic variant can be found in ~37% of all PGL patients and 55% of those with HNPGLs (Horton et al. 2022). Germline SDHB pathogenic variants are more often associated with metastatic tumors. However, this does not appear true for HNPGLs. About 8% of HNPGLs are metastatic, with CBT (12%) having the highest rate. Therefore, an SDHB germline pathogenic variant should not necessarily influence therapeutic decisions for HNPGLs. However, genetic counseling/testing is recommended for all patients with a PGL as it defines the necessity to screen for other synchronous PGLs, recommends lifelong surveillance, and is the basis for identifying other at-risk family members.

Catecholamine-secreting HNPGLs

Catecholamine-secreting HNPGLs are rare with sparse documentation of true incidence rates. This may reflect inadequate biochemical screening following initial HNPGL diagnosis or due to true lack of functional activity by tumors arising from parasympathetic ganglia. We reported a 54.3% biochemical screening rate with a 20.4% positivity rate in new HNPGLs over a 20-year period, possibly due to inadequate initial symptom assessment or patients remaining asymptomatic despite elevated catecholamines (Smith et al. 2021). A recent study reports that only 3.7% of all HNPGLs lead to elevated normetanephrine levels. Interestingly, this study also found higher levels of methoxytyramine, the O-methylated metabolite of dopamine in benign HNPGLs, which contrasts the prior suggestion of an increase in methoxytyramine and dopamine in metastatic PGLs (Richter et al. 2022). Patients with clinically significant catecholamine levels may still present asymptomatically, though symptoms may later arise. Patients should definitively be screened by measuring metanephrines; catecholamine measurement is no longer used. While there is a continued debate about superiority of plasma-free metanephrines vs urinary metanephrines, we prefer to obtain plasma metanephrines. The main reasons are: (i) 24-h urine collection is cumbersome and blood is often drawn during clinic visits anyway and (ii) patients with a PGL have a high pretest probability and thus false-positive results are less likely. Usually, normetanephrine levels must be ≥two- to three-fold elevated to be associated with hypercatecholaminergic symptoms. For borderline positive results, 24-h urine collection or blood draw while supine after 30 min rest can be conducted (Smith et al. 2021). Patients with confirmed catecholamine-secreting HNPGLs planning surgical management might need perioperative α-adrenergic and possible subsequent β-adrenergic blockades to prevent intraoperative hypertensive crises, though specific management strategies are often institution dependent, and we recognize the recent discussions around the overall necessity for blockade.

Multifocal tumors

It can be difficult to determine whether tumors are truly multifocal or metastatic. In general, if tumors are evident in typical areas in which HNPGLs arise, they are assumed to be multifocal. However, if tumors are seen in organs usually void of paraganglial cells (bone and lymph nodes) they are proven metastatic. Presurgical careful imaging, for example, employing 68Ga-DOTATAE PET scans might be helpful in selected patients with higher risk for metastatic disease (e.g. infiltrative growth on cross-sectional imaging and large tumors). The presence of metastasis should influence therapy selection, for example, STR or palliative XRT for symptomatic HNPGL and consideration of systemic therapy for metastatic disease.

Multifocal HNPGL management differs from solitary tumors and poses unique challenges. Patient age should also be considered. Patients >65 years old tend to have greater difficulty compensating for lower CN deficits following surgical resection of HNPGLs – observation with annual imaging may be more appropriate for this population (Moore et al. 2016). Tumor location, bilaterality, disease extent, and preoperative lower CN function must also be considered (Szymańska et al. 2015). Unilateral multifocal HNPGLs may be approached with a single-step surgical resection (Álvarez-Morujo et al. 2016). Bilateral tumors may be managed with a two-stage resection, with the second portion dependent on pre- and postoperative lower CN function to avoid potentially catastrophic complications from bilateral lower CN dysfunction (Szymańska et al. 2015, Moore et al. 2016). Tumor subtype is also an important consideration in multicentric tumor management. GV resection often requires CN X sacrifice; removal of the larger GV with observation and RT of the smaller tumor are reasonable approaches (Álvarez-Morujo et al. 2016). Concurrent bilateral CBT resection should be avoided due to postoperative hypertension resulting from aortic receptor dysregulation, especially when vascular repair or grafts are used; staged resections are thus preferred with >6 months between procedures (Álvarez-Morujo et al. 2016). Some surgeons prefer resection of larger tumors first (Velegrakis et al. 2001), while others first opt for the smaller tumor (Darouassi et al. 2017). For patients with different HNPGL subtypes in varying locations, management may become more complex. We recommend operation on the side with more tumors and/or tumors larger in size. Concomitant HNPGLs and abdominal pheochromocytoma suggest a hereditary syndrome; in addition to the standard genetic testing for SDHx mutations recommended for all PGL patients, plasma metanephrines testing should occur prior to surgical intervention (Smith et al. 2017).

Conclusions and future perspectives

HNPGL management approaches have changed dramatically in recent decades. Longitudinal studies have observed great surgical morbidity and conversely demonstrated safety and efficacy of natural observation to preserve lower CN functionality as long as possible. In appropriately selected asymptomatic patients, observation is a reasonable initial approach. While RT has been viewed as an adjunct or alternative treatment for poor surgical candidates, SRS and IMPT may offer local tumor control with lower morbidity compared to surgery and are increasingly viewed as first-line management. Additionally, POE may be less beneficial than previously thought. As knowledge regarding HNPGL genetics grows, management may become more patient specific. Overall, HNPGL management has shifted to more conservative approaches without compromising patient outcomes.

Declaration of interest

Tobias Else is an associate editor on the editorial board of Endocrine Oncology. Tobias Else was not involved in the review or editorial process for this paper, on which he is listed as an author. No other conflicts of interest to declare.

Funding

None.

Patient Consent

Written informed consent for the publication of clinical images in Figure 2 was obtained from the patient.

Author contribution statement

The authors contributed to the conceptualization and design, writing of original draft, review, editing, and approval of final version.

References

  • Abu-Ghanem S, Yehuda M, Carmel NN, Abergel A & Fliss DM 2016 Impact of preoperative embolization on the outcomes of carotid body tumor surgery: a meta-analysis and review of the literature. Head and Neck 38(Supplement 1) E2386E2394. (https://doi.org/10.1002/hed.24381)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Álvarez-Morujo RJ, Ruiz , Serafini DP, Delgado IL, Friedlander E & Yurrita BS 2016 Management of multicentric paragangliomas: review of 24 patients with 60 tumors. Head and Neck 38 267276. (https://doi.org/10.1002/hed.23894)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Anderson JL, Khattab MH, Anderson C, Sherry AD, Luo G, Manzoor N, Attia A, Netterville J & Cmelak AJ 2020 Long-term outcomes for the treatment of paragangliomas in the upfront, adjuvant, and salvage settings with stereotactic radiosurgery and intensity-modulated radiotherapy. Otology and Neurotology 41 133140. (https://doi.org/10.1097/MAO.0000000000002461)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Antonitsis P, Saratzis N, Velissaris I, Lazaridis I, Melas N, Ginis G, Giavroglou C & Kiskinis D 2006 Management of cervical paragangliomas: review of a 15-year experience. Langenbeck’s Archives of Surgery 391 396402. (https://doi.org/10.1007/s00423-006-0047-3)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Arya S, Rao V, Juvekar S & Dcruz AK 2008 Carotid body tumors: objective criteria to predict Shamblin group on MR imaging. American Journal of Neuroradiology 29 13491354. (https://doi.org/10.3174/ajnr.A1092)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Bacciu A, Medina M, Ait Mimoune H, D’Orazio F, Pasanisi E, Peretti G & Sanna M 2015 Lower cranial nerves function after surgical treatment of Fisch Class C and D tympanojugular paragangliomas. European Archives of Oto-Rhino-Laryngology 272 311319. (https://doi.org/10.1007/s00405-013-2862-9)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Burgess A, Calderon M, Jafif-Cojab M, Jorge D & Balanza R 2017 Bilateral carotid body tumor resection in a female patient. International Journal of Surgery Case Reports 41 387391. (https://doi.org/10.1016/j.ijscr.2017.11.019)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Carlson ML, Sweeney AD, Wanna GB, Netterville JL & Haynes DS 2015 Natural history of glomus jugulare: a review of 16 tumors managed with primary observation. Otolaryngology–Head and Neck Surgery 152 98105. (https://doi.org/10.1177/0194599814555839)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Colli BO, Junior CGC, de Oliveira RS, Gondim GGP, Abud DG, Massuda ET, de Melo Filho FV & Tanaka K 2021 Surgical management of embolized jugular foramen paragangliomas without facial nerve transposition: experience of a public tertiary hospital in Brazil. Surgical Neurology International 12 482. (https://doi.org/10.25259/SNI_651_2021)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B & Ammar H 2017 Carotid body tumors: a case series and review of the literature. Annals of Vascular Surgery 43 265271. (https://doi.org/10.1016/j.avsg.2017.03.167)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • De Marini P, Greget M, Boatta E, Jahn C, Enescu I, Garnon J, Dalili D, Cazzato RL & Gangi A 2021 Safety and technical efficacy of pre-operative embolization of head and neck paragangliomas: a 10-year mono-centric experience and systematic review. Clinical Imaging 80 292299. (https://doi.org/10.1016/j.clinimag.2021.08.014)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fathalla AE & Elalfy MA 2020 Clinical outcome of carotid body paraganglioma management: a review of 10-year experience. Journal of Oncology 2020 6081273. (https://doi.org/10.1155/2020/6081273)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fatima N, Pollom E, Soltys S, Chang SD & Meola A 2021 Stereotactic radiosurgery for head and neck paragangliomas: a systematic review and meta-analysis. Neurosurgical Review 44 741752. (https://doi.org/10.1007/s10143-020-01292-5)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fermi M, Ferri G, Bayoumi Ebaied T, Alicandri-Ciufelli M, Bonali M, Badr El-Dine M & Presutti L 2021 Transcanal endoscopic management of glomus tympanicum: multicentric case series. Otology and Neurotology 42 312318. (https://doi.org/10.1097/MAO.0000000000002929)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gaillard F. Distribution of paragangliomas. In Radiopaedia. Melbourne, Australia: Radiopaedia Australia Pty Ltd. (https://doi.org/10.53347/rID-36089)

    • Crossref
    • PubMed
    • Export Citation
  • Gandía-González ML, Kusak ME, Moreno NM, Sárraga JG, Rey G & Álvarez RM 2014 Jugulotympanic paragangliomas treated with gamma Knife radiosurgery: a single-center review of 58 cases. Journal of Neurosurgery 121 11581165. (https://doi.org/10.3171/2014.5.JNS131880)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gottlieb E & Tomlinson IP 2005 Mitochondrial tumour suppressors: a genetic and biochemical update. Nature Reviews. Cancer 5 857866. (https://doi.org/10.1038/nrc1737)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Griauzde J, Gemmete JJ, Chaudhary N, Pandey AS, Sullivan SE, McKean EL & Marentette LJ 2013 A comparison of particulate and Onyx embolization in preoperative devascularization of carotid body tumors. Neuroradiology 55 11131118. (https://doi.org/10.1007/s00234-013-1220-3)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gupta AK, Purkayastha S, Bodhey NK, Kapilamoorthy TR & Kesavadas C 2007 Preoperative embolization of hypervascular head and neck tumours. Australian Radiology 51 446452. (https://doi.org/10.1111/j.1440-1673.2007.01869.x)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Harrison LB, Sessions RB & & Hong WK 2009 Head and neck cancer: a multidisciplinary approach, 3rd ed. Philadelphia, PA, USA: Lippincott Williams and Wilkins.

  • Heesterman BL, de Pont LMH, Verbist BM, van der Mey AGL, Corssmit EPM, Hes FJ, van Benthem PPG & Jansen JC 2017 Age and tumor volume predict growth of carotid and vagal body paragangliomas. Journal of Neurological Surgery. Part B, Skull Base 78 497505. (https://doi.org/10.1055/s-0037-1604347)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Helal A, Vakharia K, Brinjikji W, Carlson ML, Driscoll CL, Van Gompel JJ, Link MJ & Cloft H 2022 Preoperative embolization of jugular paraganglioma tumors using particles is safe and effective. Interventional Neuroradiology 28 145151. (https://doi.org/10.1177/15910199211019175)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Horton C, LaDuca H, Deckman A, Durda K, Jackson M, Richardson ME, Tian Y, Yussuf A, Jasperson K & Else T 2022 Universal germline panel testing for individuals with pheochromocytoma and paraganglioma produces high diagnostic yield. Journal of Clinical Endocrinology and Metabolism 107 e1917–e1923. (https://doi.org/10.1210/clinem/dgac014)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Ikram A & Rehman A 2022 Paraganglioma. In StatPearls. Treasure Island, FL, USA: StatPearls Publishing. (available at: https://www.ncbi.nlm.nih.gov/books/NBK549834/)

  • Jackson CG, McGrew BM, Forest JA, Netterville JL, Hampf CF & Glasscock ME 2001 Lateral skull base surgery for glomus tumors: long-term control, 3rd ed. Otology and Neurotology 22 377382. (https://doi.org/10.1097/00129492-200105000-00018)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jang M, Liu H & Dai C 2018 The application of sigmoid sinus tunnel-packing or push-packing of the inferior petrous sinus in the microsurgical management of jugular paragangliomas. Otology and Neurotology 39 e166e172. (https://doi.org/10.1097/MAO.0000000000001683)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jansen TTG, Timmers HJLM, Marres HAM, Kaanders JHAM & Kunst HPM 2018 Results of a systematic literature review of treatment modalities for jugulotympanic paraganglioma, stratified per Fisch class. Clinical Otolaryngology 43 652661. (https://doi.org/10.1111/coa.13046)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jansen TTG, Timmers HJLM, Marres HAM & Kunst HPM 2017 Feasibility of a wait-and-scan period as initial management strategy for head and neck paraganglioma. Head and Neck 39 20882094. (https://doi.org/10.1002/hed.24871)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Katagiri K, Shiga K, Ikeda A, Saito D, Oikawa SI, Tschuchida K, Miyaguchi J, Tamura A, Nakasato T & Ehara S et al.2019 Effective, same-day preoperative embolization and surgical resection of carotid body tumors. Head and Neck 41 31593167. (https://doi.org/10.1002/hed.25805)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Killeen DE, Wick CC, Hunter JB, Rivas A, Wanna GB, Nogueira JF, Kutz JW & Isaacson B 2017 Endoscopic management of middle ear paragangliomas: a case series. Otology and Neurotology 38 408415. (https://doi.org/10.1097/MAO.0000000000001320)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Kimura N, Shiga K, Kaneko KI, Oki Y, Sugisawa C, Saito J, Tawara S, Akahori H, Sogabe S & Yamashita T et al.2021 Immunohistochemical expression of choline acetyltransferase and catecholamine-synthesizing enzymes in head-and-neck and thoracoabdominal paragangliomas and pheochromocytomas. Endocrine Pathology 32 442451. (https://doi.org/10.1007/s12022-021-09694-x)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Kocur D, Ślusarczyk W, Przybyłko N, Hofman M, Jamróz T, Suszyński K, Baron J & Kwiek S 2017 Endovascular approach to glomus jugulare tumors. Polish Journal of Radiology 82 322326. (https://doi.org/10.12659/PJR.901141)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Lassen-Ramshad Y, Ozyar E, Alanyali S, Poortmans P, van Houtte P, Sohawon S, Esassolak M, Krengli M, Villa S & Miller R et al.2019 Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study. Head and Neck 41 17701776. (https://doi.org/10.1002/hed.25611)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Li J, Wang S, Zee C, Yang J, Chen W, Zhuang W, Li X, Lv W, Huang Y & Li S 2010 Preoperative angiography and transarterial embolization in the management of carotid body tumor: a single-center, 10-year experience. Neurosurgery 67 941948. (https://doi.org/10.1227/NEU.0b013e3181eda61d)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Li L, Xu H, Zhou J, Mydlarz WK, Yuu Z, Chen X & London NR 2021 Resection of carotid body tumors in patients of advanced age: experience from a single center. Ear, Nose, and Throat Journal 102 45-51. (https://doi.org/10.1177/0145561320981442)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Lieberson RE, Adler JR, Soltys SG, Choi C, Gibbs IC & Chang SD 2012 Stereotactic radiosurgery as the primary treatment for new and recurrent paragangliomas: is open surgical resection still the treatment of choice? World Neurosurgery 77 745761. (https://doi.org/10.1016/j.wneu.2011.03.026)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Liu J, Li Y, Yang L & Cai H 2018 Surgical resection of carotid body tumors with versus without preoperative embolization: retrospective case-control study. Head and Neck 40 25902595. (https://doi.org/10.1002/hed.25387)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Manzoor NF, Yancey KL, Aulino JM, Sherry AD, Khattan MH, Cmelak A, Morrel WG, Haynes DS, Bennett ML & O’Malley MR et al.2021 Contemporary management of jugular paragangliomas with neural preservation. Otolaryngology–Head and Neck Surgery 164 391398. (https://doi.org/10.1177/0194599820938660)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Mendenhall WM, Hinerman RW, Amdur RJ, Stringer SP, Antonelli PJ, Singleton GT & Cassisi NJ 2001 Treatment of paragangliomas with radiation therapy. Otolaryngologic Clinics of North America 34 10071020. (https://doi.org/10.1016/s0030-6665(0570360-1)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Miller JP, Semaan M, Einstein D, Megerian CA & Maciunas RJ 2009 Staged gamma Knife radiosurgery after tailored surgical resection: a novel treatment paradigm for glomus jugulare tumors. Stereotactic and Functional Neurosurgery 87 3136. (https://doi.org/10.1159/000195717)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Moore MG, Netterville JL, Mendenhall WM, Isaacson B & Nussenbaum B 2016 Head and neck paragangliomas: an update on evaluation and management. Otolaryngology–Head and Neck Surgery 154 597605. (https://doi.org/10.1177/0194599815627667)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Myssiorek D, Rinaldo A, Barnes L & Ferlito A 2004 Laryngeal paraganglioma: an updated critical review. Acta Otolaryngologica 124 995999. (https://doi.org/10.1080/00016480410017576)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Netterville JL, Jackson CG, Miller FR, Wanamaker JR & Glasscock ME 1998 Vagal paraganglioma: a review of 46 patients treated during a 20-year period. Archives of Otolaryngology–Head and Neck Surgery 124 11331140. (https://doi.org/10.1001/archotol.124.10.1133)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Nguyen ML, Cantrell JN, Ahmad S & Henson C 2021 Intensity-modulated proton therapy versus intensity-modulated radiation therapy for the treatment of head and neck cancer: a dosimetric comparison. Medical Dosimetry 46 259263. (https://doi.org/10.1016/j.meddos.2021.02.001)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Offergeld C, Brase C, Yaremchuk S, Mader I, Rischke HC, Gläsker S, Schmid KW, Wiech T, Preuss SF & Suárez C et al.2012 Head and neck paragangliomas: clinical and molecular genetic classification. Clinics 67(Supplement 1) 1928. (https://doi.org/10.6061/clinics/2012(sup0105)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Prasad SC, Laus M, Al-Ghamdi S, Vashishth A, Piazza P & Sanna M 2019 Update in the classification and the role of intra-arterial stenting in the management of carotid body paragangliomas. Head and Neck 41 13791386. (https://doi.org/10.1002/hed.25567)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Prasad SC, Paties CT, Pantalone MR, Mariani-Costantini R & Sanna M 2019 Carotid body and vagal paragangliomas: epidemiology, genetics, clinicopathological features, imaging, and surgical management. In Mariani-Costantini Red. Paraganglioma: a multidisciplinary approach. Brisbane, AU: Codon Publications. (https://doi.org/10.15586/paraganglioma.2019.ch5)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Richter S, Qiu B, Ghering M, Kunath C, Constantinescu G, Luths C, Pamporaki C, Bechmann N, Meuter L & Kwapiszewska A et al.2022 Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine. Endocrine-Related Cancer 29 213224. (https://doi.org/10.1530/ERC-21-0359)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Seth R, Ahmed M, Hoschar AP, Wood BG & Scharpf J 2014 Cervical sympathetic chain paraganglioma: a report of 2 cases and a literature review. Ear, Nose, and Throat Journal 93 E22E27.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Shamblin WR, ReMine WH, Sheps SG & Harrison EGJ 1971 Carotid body tumor (chemodectoma). American Journal of Surgery 122 732739. (https://doi.org/10.1016/0002-9610(7190436-3)

  • Shin SH, Piazza P, De Donato G, Sivalingam S, Lauda L, Vitullo F & Sanna M 2012 Management of vagal paragangliomas including application of internal carotid artery stenting. Audiology and Neuro-Otology 17 3953. (https://doi.org/10.1159/000329213)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Smith JD, Ellsperman SE, Basura GJ & Else T 2021 Re-evaluating the prevalence and factors characteristic of catecholamine secreting head and neck paragangliomas. Endocrinology, Diabetes and Metabolism 4 e00256. (https://doi.org/10.1002/edm2.256)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Smith JD, Harvey RN, Darr OA, Prince ME, Bradford CR, Wolf GT, Else T & Basura GJ 2017 Head and neck paragangliomas: a two-decade institutional experience and algorithm for management. Laryngoscope Investigative Otolaryngology 2 380389. (https://doi.org/10.1002/lio2.122)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Sweeney AD, Carlson ML, Wanna GB & Bennett ML 2015 Glomus tympanicum tumors. Otolaryngologic Clinics of North America 48 293304. (https://doi.org/10.1016/j.otc.2014.12.004)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Szymańska A, Szymański M, Czekajska-Chehab E, Gołąbek W & Szczerbo-Trojanowska M 2015 Diagnosis and management of multiple paragangliomas of the head and neck. European Archives of Oto-Rhino-Laryngology 272 19911999. (https://doi.org/10.1007/s00405-014-3126-z)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • van Hulsteijn LT, Corssmit EPM, Coremans IEM, Smit JWA, Jansen JC & Dekkers OM 2013 Regression and local control rates after radiotherapy for jugulotympanic paragangliomas: systematic review and meta-analysis. Radiotherapy and Oncology 106 161168. (https://doi.org/10.1016/j.radonc.2012.11.002)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Velegrakis G, Kalikakis G, Karampekios S, Stefanaki K & Helidonis E 2001 Bilateral paraganglioma of the vagus nerve. HNO 49 471475. (https://doi.org/10.1007/s001060170099)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Vora AA, Lai CK, Rao JY, Apple SK & Moatamed NA 2012 Paraganglioma with unusual presentation in parotid gland: a diagnostic dilemma in fine needle aspiration. CytoJournal 9 26. (https://doi.org/10.4103/1742-6413.105119)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Walker DD & Babu S 2019 Temporal bone paraganglioma: hearing outcomes and rehabilitation. Journal of Neurological Surgery. Part B, Skull Base 80 209213. (https://doi.org/10.1055/s-0039-1679890)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Yildiz E, Dahm V, Gstoettner W, Rössler K, Bauer B, Wressnegger A, Schwarz-Nemec U, Gatterbauer B, Matula C & Arnolder C 2021 Long-term outcome and comparison of treatment modalities of temporal bone paragangliomas. Cancers 13 5083. (https://doi.org/10.3390/cancers13205083)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation

 

  • Collapse
  • Expand
  • Figure 1

    HNPGL subsites. Figure 1 was drawn based on images from Harrison (2009) and Gaillard (2015).

  • Figure 3

    Intraoperative transmastoid approach of glomus jugulare invading up and through the skull base, the middle ear, through the ear canal, and eroding CN VII. The tumor was debulked prior to cable-grafting CN VII and over-closing the ear canal to prevent cholesteatoma.

  • Figure 2

    Axial post-contrast MRI findings for Shamblin class I CBT (A), class II CBT (B), and class III CBT (C).

  • Abu-Ghanem S, Yehuda M, Carmel NN, Abergel A & Fliss DM 2016 Impact of preoperative embolization on the outcomes of carotid body tumor surgery: a meta-analysis and review of the literature. Head and Neck 38(Supplement 1) E2386E2394. (https://doi.org/10.1002/hed.24381)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Álvarez-Morujo RJ, Ruiz , Serafini DP, Delgado IL, Friedlander E & Yurrita BS 2016 Management of multicentric paragangliomas: review of 24 patients with 60 tumors. Head and Neck 38 267276. (https://doi.org/10.1002/hed.23894)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Anderson JL, Khattab MH, Anderson C, Sherry AD, Luo G, Manzoor N, Attia A, Netterville J & Cmelak AJ 2020 Long-term outcomes for the treatment of paragangliomas in the upfront, adjuvant, and salvage settings with stereotactic radiosurgery and intensity-modulated radiotherapy. Otology and Neurotology 41 133140. (https://doi.org/10.1097/MAO.0000000000002461)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Antonitsis P, Saratzis N, Velissaris I, Lazaridis I, Melas N, Ginis G, Giavroglou C & Kiskinis D 2006 Management of cervical paragangliomas: review of a 15-year experience. Langenbeck’s Archives of Surgery 391 396402. (https://doi.org/10.1007/s00423-006-0047-3)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Arya S, Rao V, Juvekar S & Dcruz AK 2008 Carotid body tumors: objective criteria to predict Shamblin group on MR imaging. American Journal of Neuroradiology 29 13491354. (https://doi.org/10.3174/ajnr.A1092)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Bacciu A, Medina M, Ait Mimoune H, D’Orazio F, Pasanisi E, Peretti G & Sanna M 2015 Lower cranial nerves function after surgical treatment of Fisch Class C and D tympanojugular paragangliomas. European Archives of Oto-Rhino-Laryngology 272 311319. (https://doi.org/10.1007/s00405-013-2862-9)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Burgess A, Calderon M, Jafif-Cojab M, Jorge D & Balanza R 2017 Bilateral carotid body tumor resection in a female patient. International Journal of Surgery Case Reports 41 387391. (https://doi.org/10.1016/j.ijscr.2017.11.019)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Carlson ML, Sweeney AD, Wanna GB, Netterville JL & Haynes DS 2015 Natural history of glomus jugulare: a review of 16 tumors managed with primary observation. Otolaryngology–Head and Neck Surgery 152 98105. (https://doi.org/10.1177/0194599814555839)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Colli BO, Junior CGC, de Oliveira RS, Gondim GGP, Abud DG, Massuda ET, de Melo Filho FV & Tanaka K 2021 Surgical management of embolized jugular foramen paragangliomas without facial nerve transposition: experience of a public tertiary hospital in Brazil. Surgical Neurology International 12 482. (https://doi.org/10.25259/SNI_651_2021)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Darouassi Y, Alaoui M, Mliha Touati M, Al Maghraoui O, En-Nouali A, Bouaity B & Ammar H 2017 Carotid body tumors: a case series and review of the literature. Annals of Vascular Surgery 43 265271. (https://doi.org/10.1016/j.avsg.2017.03.167)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • De Marini P, Greget M, Boatta E, Jahn C, Enescu I, Garnon J, Dalili D, Cazzato RL & Gangi A 2021 Safety and technical efficacy of pre-operative embolization of head and neck paragangliomas: a 10-year mono-centric experience and systematic review. Clinical Imaging 80 292299. (https://doi.org/10.1016/j.clinimag.2021.08.014)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fathalla AE & Elalfy MA 2020 Clinical outcome of carotid body paraganglioma management: a review of 10-year experience. Journal of Oncology 2020 6081273. (https://doi.org/10.1155/2020/6081273)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fatima N, Pollom E, Soltys S, Chang SD & Meola A 2021 Stereotactic radiosurgery for head and neck paragangliomas: a systematic review and meta-analysis. Neurosurgical Review 44 741752. (https://doi.org/10.1007/s10143-020-01292-5)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Fermi M, Ferri G, Bayoumi Ebaied T, Alicandri-Ciufelli M, Bonali M, Badr El-Dine M & Presutti L 2021 Transcanal endoscopic management of glomus tympanicum: multicentric case series. Otology and Neurotology 42 312318. (https://doi.org/10.1097/MAO.0000000000002929)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gaillard F. Distribution of paragangliomas. In Radiopaedia. Melbourne, Australia: Radiopaedia Australia Pty Ltd. (https://doi.org/10.53347/rID-36089)

    • Crossref
    • PubMed
    • Export Citation
  • Gandía-González ML, Kusak ME, Moreno NM, Sárraga JG, Rey G & Álvarez RM 2014 Jugulotympanic paragangliomas treated with gamma Knife radiosurgery: a single-center review of 58 cases. Journal of Neurosurgery 121 11581165. (https://doi.org/10.3171/2014.5.JNS131880)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gottlieb E & Tomlinson IP 2005 Mitochondrial tumour suppressors: a genetic and biochemical update. Nature Reviews. Cancer 5 857866. (https://doi.org/10.1038/nrc1737)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Griauzde J, Gemmete JJ, Chaudhary N, Pandey AS, Sullivan SE, McKean EL & Marentette LJ 2013 A comparison of particulate and Onyx embolization in preoperative devascularization of carotid body tumors. Neuroradiology 55 11131118. (https://doi.org/10.1007/s00234-013-1220-3)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Gupta AK, Purkayastha S, Bodhey NK, Kapilamoorthy TR & Kesavadas C 2007 Preoperative embolization of hypervascular head and neck tumours. Australian Radiology 51 446452. (https://doi.org/10.1111/j.1440-1673.2007.01869.x)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Harrison LB, Sessions RB & & Hong WK 2009 Head and neck cancer: a multidisciplinary approach, 3rd ed. Philadelphia, PA, USA: Lippincott Williams and Wilkins.

  • Heesterman BL, de Pont LMH, Verbist BM, van der Mey AGL, Corssmit EPM, Hes FJ, van Benthem PPG & Jansen JC 2017 Age and tumor volume predict growth of carotid and vagal body paragangliomas. Journal of Neurological Surgery. Part B, Skull Base 78 497505. (https://doi.org/10.1055/s-0037-1604347)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Helal A, Vakharia K, Brinjikji W, Carlson ML, Driscoll CL, Van Gompel JJ, Link MJ & Cloft H 2022 Preoperative embolization of jugular paraganglioma tumors using particles is safe and effective. Interventional Neuroradiology 28 145151. (https://doi.org/10.1177/15910199211019175)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Horton C, LaDuca H, Deckman A, Durda K, Jackson M, Richardson ME, Tian Y, Yussuf A, Jasperson K & Else T 2022 Universal germline panel testing for individuals with pheochromocytoma and paraganglioma produces high diagnostic yield. Journal of Clinical Endocrinology and Metabolism 107 e1917–e1923. (https://doi.org/10.1210/clinem/dgac014)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Ikram A & Rehman A 2022 Paraganglioma. In StatPearls. Treasure Island, FL, USA: StatPearls Publishing. (available at: https://www.ncbi.nlm.nih.gov/books/NBK549834/)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jackson CG, McGrew BM, Forest JA, Netterville JL, Hampf CF & Glasscock ME 2001 Lateral skull base surgery for glomus tumors: long-term control, 3rd ed. Otology and Neurotology 22 377382. (https://doi.org/10.1097/00129492-200105000-00018)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jang M, Liu H & Dai C 2018 The application of sigmoid sinus tunnel-packing or push-packing of the inferior petrous sinus in the microsurgical management of jugular paragangliomas. Otology and Neurotology 39 e166e172. (https://doi.org/10.1097/MAO.0000000000001683)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jansen TTG, Timmers HJLM, Marres HAM, Kaanders JHAM & Kunst HPM 2018 Results of a systematic literature review of treatment modalities for jugulotympanic paraganglioma, stratified per Fisch class. Clinical Otolaryngology 43 652661. (https://doi.org/10.1111/coa.13046)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Jansen TTG, Timmers HJLM, Marres HAM & Kunst HPM 2017 Feasibility of a wait-and-scan period as initial management strategy for head and neck paraganglioma. Head and Neck 39 20882094. (https://doi.org/10.1002/hed.24871)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Katagiri K, Shiga K, Ikeda A, Saito D, Oikawa SI, Tschuchida K, Miyaguchi J, Tamura A, Nakasato T & Ehara S et al.2019 Effective, same-day preoperative embolization and surgical resection of carotid body tumors. Head and Neck 41 31593167. (https://doi.org/10.1002/hed.25805)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Killeen DE, Wick CC, Hunter JB, Rivas A, Wanna GB, Nogueira JF, Kutz JW & Isaacson B 2017 Endoscopic management of middle ear paragangliomas: a case series. Otology and Neurotology 38 408415. (https://doi.org/10.1097/MAO.0000000000001320)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Kimura N, Shiga K, Kaneko KI, Oki Y, Sugisawa C, Saito J, Tawara S, Akahori H, Sogabe S & Yamashita T et al.2021 Immunohistochemical expression of choline acetyltransferase and catecholamine-synthesizing enzymes in head-and-neck and thoracoabdominal paragangliomas and pheochromocytomas. Endocrine Pathology 32 442451. (https://doi.org/10.1007/s12022-021-09694-x)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Kocur D, Ślusarczyk W, Przybyłko N, Hofman M, Jamróz T, Suszyński K, Baron J & Kwiek S 2017 Endovascular approach to glomus jugulare tumors. Polish Journal of Radiology 82 322326. (https://doi.org/10.12659/PJR.901141)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Lassen-Ramshad Y, Ozyar E, Alanyali S, Poortmans P, van Houtte P, Sohawon S, Esassolak M, Krengli M, Villa S & Miller R et al.2019 Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study. Head and Neck 41 17701776. (https://doi.org/10.1002/hed.25611)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Li J, Wang S, Zee C, Yang J, Chen W, Zhuang W, Li X, Lv W, Huang Y & Li S 2010 Preoperative angiography and transarterial embolization in the management of carotid body tumor: a single-center, 10-year experience. Neurosurgery 67 941948. (https://doi.org/10.1227/NEU.0b013e3181eda61d)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Li L, Xu H, Zhou J, Mydlarz WK, Yuu Z, Chen X & London NR 2021 Resection of carotid body tumors in patients of advanced age: experience from a single center. Ear, Nose, and Throat Journal 102 45-51. (https://doi.org/10.1177/0145561320981442)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Lieberson RE, Adler JR, Soltys SG, Choi C, Gibbs IC & Chang SD 2012 Stereotactic radiosurgery as the primary treatment for new and recurrent paragangliomas: is open surgical resection still the treatment of choice? World Neurosurgery 77 745761. (https://doi.org/10.1016/j.wneu.2011.03.026)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Liu J, Li Y, Yang L & Cai H 2018 Surgical resection of carotid body tumors with versus without preoperative embolization: retrospective case-control study. Head and Neck 40 25902595. (https://doi.org/10.1002/hed.25387)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Manzoor NF, Yancey KL, Aulino JM, Sherry AD, Khattan MH, Cmelak A, Morrel WG, Haynes DS, Bennett ML & O’Malley MR et al.2021 Contemporary management of jugular paragangliomas with neural preservation. Otolaryngology–Head and Neck Surgery 164 391398. (https://doi.org/10.1177/0194599820938660)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Mendenhall WM, Hinerman RW, Amdur RJ, Stringer SP, Antonelli PJ, Singleton GT & Cassisi NJ 2001 Treatment of paragangliomas with radiation therapy. Otolaryngologic Clinics of North America 34 10071020. (https://doi.org/10.1016/s0030-6665(0570360-1)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Miller JP, Semaan M, Einstein D, Megerian CA & Maciunas RJ 2009 Staged gamma Knife radiosurgery after tailored surgical resection: a novel treatment paradigm for glomus jugulare tumors. Stereotactic and Functional Neurosurgery 87 3136. (https://doi.org/10.1159/000195717)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Moore MG, Netterville JL, Mendenhall WM, Isaacson B & Nussenbaum B 2016 Head and neck paragangliomas: an update on evaluation and management. Otolaryngology–Head and Neck Surgery 154 597605. (https://doi.org/10.1177/0194599815627667)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Myssiorek D, Rinaldo A, Barnes L & Ferlito A 2004 Laryngeal paraganglioma: an updated critical review. Acta Otolaryngologica 124 995999. (https://doi.org/10.1080/00016480410017576)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Netterville JL, Jackson CG, Miller FR, Wanamaker JR & Glasscock ME 1998 Vagal paraganglioma: a review of 46 patients treated during a 20-year period. Archives of Otolaryngology–Head and Neck Surgery 124 11331140. (https://doi.org/10.1001/archotol.124.10.1133)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Nguyen ML, Cantrell JN, Ahmad S & Henson C 2021 Intensity-modulated proton therapy versus intensity-modulated radiation therapy for the treatment of head and neck cancer: a dosimetric comparison. Medical Dosimetry 46 259263. (https://doi.org/10.1016/j.meddos.2021.02.001)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Offergeld C, Brase C, Yaremchuk S, Mader I, Rischke HC, Gläsker S, Schmid KW, Wiech T, Preuss SF & Suárez C et al.2012 Head and neck paragangliomas: clinical and molecular genetic classification. Clinics 67(Supplement 1) 1928. (https://doi.org/10.6061/clinics/2012(sup0105)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Prasad SC, Laus M, Al-Ghamdi S, Vashishth A, Piazza P & Sanna M 2019 Update in the classification and the role of intra-arterial stenting in the management of carotid body paragangliomas. Head and Neck 41 13791386. (https://doi.org/10.1002/hed.25567)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Prasad SC, Paties CT, Pantalone MR, Mariani-Costantini R & Sanna M 2019 Carotid body and vagal paragangliomas: epidemiology, genetics, clinicopathological features, imaging, and surgical management. In Mariani-Costantini Red. Paraganglioma: a multidisciplinary approach. Brisbane, AU: Codon Publications. (https://doi.org/10.15586/paraganglioma.2019.ch5)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Richter S, Qiu B, Ghering M, Kunath C, Constantinescu G, Luths C, Pamporaki C, Bechmann N, Meuter L & Kwapiszewska A et al.2022 Head/neck paragangliomas: focus on tumor location, mutational status and plasma methoxytyramine. Endocrine-Related Cancer 29 213224. (https://doi.org/10.1530/ERC-21-0359)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Seth R, Ahmed M, Hoschar AP, Wood BG & Scharpf J 2014 Cervical sympathetic chain paraganglioma: a report of 2 cases and a literature review. Ear, Nose, and Throat Journal 93 E22E27.

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Shamblin WR, ReMine WH, Sheps SG & Harrison EGJ 1971 Carotid body tumor (chemodectoma). American Journal of Surgery 122 732739. (https://doi.org/10.1016/0002-9610(7190436-3)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Shin SH, Piazza P, De Donato G, Sivalingam S, Lauda L, Vitullo F & Sanna M 2012 Management of vagal paragangliomas including application of internal carotid artery stenting. Audiology and Neuro-Otology 17 3953. (https://doi.org/10.1159/000329213)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Smith JD, Ellsperman SE, Basura GJ & Else T 2021 Re-evaluating the prevalence and factors characteristic of catecholamine secreting head and neck paragangliomas. Endocrinology, Diabetes and Metabolism 4 e00256. (https://doi.org/10.1002/edm2.256)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Smith JD, Harvey RN, Darr OA, Prince ME, Bradford CR, Wolf GT, Else T & Basura GJ 2017 Head and neck paragangliomas: a two-decade institutional experience and algorithm for management. Laryngoscope Investigative Otolaryngology 2 380389. (https://doi.org/10.1002/lio2.122)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Sweeney AD, Carlson ML, Wanna GB & Bennett ML 2015 Glomus tympanicum tumors. Otolaryngologic Clinics of North America 48 293304. (https://doi.org/10.1016/j.otc.2014.12.004)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Szymańska A, Szymański M, Czekajska-Chehab E, Gołąbek W & Szczerbo-Trojanowska M 2015 Diagnosis and management of multiple paragangliomas of the head and neck. European Archives of Oto-Rhino-Laryngology 272 19911999. (https://doi.org/10.1007/s00405-014-3126-z)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • van Hulsteijn LT, Corssmit EPM, Coremans IEM, Smit JWA, Jansen JC & Dekkers OM 2013 Regression and local control rates after radiotherapy for jugulotympanic paragangliomas: systematic review and meta-analysis. Radiotherapy and Oncology 106 161168. (https://doi.org/10.1016/j.radonc.2012.11.002)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Velegrakis G, Kalikakis G, Karampekios S, Stefanaki K & Helidonis E 2001 Bilateral paraganglioma of the vagus nerve. HNO 49 471475. (https://doi.org/10.1007/s001060170099)

  • Vora AA, Lai CK, Rao JY, Apple SK & Moatamed NA 2012 Paraganglioma with unusual presentation in parotid gland: a diagnostic dilemma in fine needle aspiration. CytoJournal 9 26. (https://doi.org/10.4103/1742-6413.105119)

    • Crossref
    • PubMed
    • Search Google Scholar
    • Export Citation
  • Walker DD & Babu S 2019 Temporal bone paraganglioma: hearing outcomes and rehabilitation. Journal of Neurological Surgery. Part B, Skull Base 80 209213. (https://doi.org/10.1055/s-0039-1679890)

    • PubMed
    • Search Google Scholar
    • Export Citation
  • Yildiz E, Dahm V, Gstoettner W, Rössler K, Bauer B, Wressnegger A, Schwarz-Nemec U, Gatterbauer B, Matula C & Arnolder C 2021 Long-term outcome and comparison of treatment modalities of temporal bone paragangliomas. Cancers 13 5083. (https://doi.org/10.3390/cancers13205083)

    • PubMed
    • Search Google Scholar
    • Export Citation