oncocytoma was discovered in 1986 ( Kakimoto et al. 1986 ), and since then, more than 150 cases have been reported in the literature ( Peynirci et al. 2018 ). Malignant OAN is reported to have a more favourable outcome with a superior 5-year survival
Eleanor Fewings, Serena Khoo Sert Kim, Alexey Larionov, Alison Marker, Olivier Giger, Ashley Shaw, Graeme R Clark, Vasilis Kosmoliaptsis, Benjamin G Challis, Marc Tischkowitz, and Ruth T Casey
Trinidad Raices, María Luisa Varela, Adriana María Belén Abiuso, Elba N Pereyra, Carolina Mondillo, Omar P Pignataro, and María Fernanda Riera
. 2019 ). Approximately 10% of Leydig cell tumours are malignant and do not respond to chemotherapy and radiotherapy. In these cases, the treatment consists of orchidectomy and early retroperitoneal lymphadenectomy to prevent metastases and achieve a long
Stéphanie Larose, Dany Rioux, Roula Albadine, and Andre Lacroix
Ectopic ACTH secretion (EAS) is a rare cause of ACTH-dependent Cushing’s syndrome (CS), most often caused by a thoracic neuroendocrine tumor (NET). Large-cell neuroendocrine carcinomas (LCNEC) with EAS are rare and usually present a more severe ACTH secretion and hypercortisolism. We report a 44-yo non-smoker man, who presented clinical and biochemical evidence of ACTH-dependent CS. Desmopressin 10 mcg iv produced a 157% increase in ACTH and a 25% increase in cortisol from baseline; there was no stimulation of ACTH or cortisol during the CRH test and no suppression with high dose dexamethasone. Pituitary MRI identified a 5 mm lesion, but inferior petrosal venous sinus sampling (IPSS) under desmopressin did not identify a central ACTH source. Thorax and abdominal imaging identified a left lung micronodule. Surgery confirmed a lung LCNEC with strongly positive ACTH immunohistochemistry (IHC) in the primary and lymph node metastasis The patient was in CS remission after surgery and adjuvant chemotherapy, but developed a recurrence 9.5 years later, with LCNEC pulmonary left hilar metastases, ectopic CS, and positive ACTH IHC. This is the first report of LCNEC, with morphologic feature of carcinoid tumor of the lung with ectopic ACTH stimulated by desmopressin. Long delay prior to metastatic recurrence indicates relatively indolent NET. This case report indicates that response to desmopressin, which usually occurs in Cushing’s disease or benign neuroendocrine tumors, can occur in malignant LCNEC.
Nada Younes, Isabelle Bourdeau, Harold Olney, Paul Perrotte, Odile Prosmanne, Mathieu Latour, David Roberge, and André Lacroix
Background Tumor seeding or needle tract implantation is a rare complication of percutaneous biopsy in which malignant cells are implanted along the trajectory of the needle, thereby increasing cancer recurrence risk ( Robertson & Baxter 2011
Syed Ehsanullah and Nikolaos A Trikalinos
. Moreover, malignant tumors more frequently demonstrate IGF2 promoter hypermethylation ( Fonseca et al. 2012 ). The effect of hypomethylating agents such as decitabine for the treatment of NENs is not well established but there is a signal pointing to
D Mc Donald, M Sherlock, and C J Thompson
clear whether the shortened survival is due directly to the electrolyte imbalance or whether hyponatraemia is a manifestation of more widespread or aggressive disease. In this review, we will summarise the data on SIAD in malignant disease and discuss
Edward P Gelmann
hope to see a better understanding of the role of regulatory RNA in disease behavior and perhaps the identification of candidate RNA species that have clinical utility. Cell surface receptors are unique markers for some malignant cells. Major
T U Kars, M Kulaksızoğlu, and İ Kılınç
). Approximately 5–15% of thyroid nodules are malignant ( Hegedüs 2004 ). Thyroid nodules are initially examined by fine-needle aspiration biopsy (FNAB), but the frequent indeterminate or suspicious FNAB results are challenging in terms of defining an appropriate
Sandra Pekic, Marko Stojanovic, and Vera Popovic
patients with pituitary adenomas are at increased risk of malignant tumors ( Popovic et al. 1998 , Boguszewski & Ayuk 2016 , Olsson et al. 2017 ). The incidence of malignancy was studied in patients with chronic excess of growth hormone (acromegaly
Sofia Maria Lider Burciulescu, Caren Randon, Frederic Duprez, Wouter Huvenne, David Creytens, Kathleen B M Claes, Robin de Putter, Guy T’Sjoen, Corin Badiu, and Bruno Lapauw
suggestive features of hereditary PPGL are familial history of the disease, bilateral cancers affecting paired organs, multiple primary PPGL in the same individual, recurrent or malignant disease, and early age of onset (i.e. <45 years old) ( Amar et al
