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Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Rosa Catalano Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Federica Mangili Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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Introduction Cell cytoskeleton proteins’ involvement in tumor pathogenesis, development and pharmacological resistance has been extensively explored in the last decades. Among these, Filamin A (FLNA), also known as actin-binding protein 280

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Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy

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last years, some molecular factors playing a role in the modulation of SSTR5 expression and activity in ACTH-secreting PitNET cells have been identified. In particular, the cytoskeleton actin-binding protein filamin A (FLNA) and the mutational status of

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Damien A Leach Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK

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Rayzel C Fernandes Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK

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Charlotte L Bevan Division of Cancer, Imperial Centre for Translational & Experimental Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK

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other cell types ( Pope & Bresnick 2013 ). Interestingly, in fibroblasts, there appears to be a relationship between proteins involved in cell movement and AR. Filamin A (FLNA) is a protein involved in linking the cytoskeleton and the plasma membrane

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