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. 2020 ). The most common are well-differentiated bronchial NETs and small-cell carcinomas ( Rekhtman 2022 ). We describe a rare case of EAS from a large-cell neuroendocrine carcinoma (LCNEC) ‘with morphologic features of carcinoid tumor’ of the lung
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1), bronchial NETs ( Pelosi et al. 2010 ) (RASSF1A), as well as Merkel cell carcinomas ( Lassacher et al. 2008 ) (RASSF1A). Adrenocortical cancers are generally hypomethylated but there is literature in hypermethylation of CDKN2A and GATA4
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tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). There are four grades for NENs: NET G1 (Ki-67 index <3%), NET G2 (Ki-67 index 3–20%), NET G3 (Ki-67 index >20%) and NEC (Ki-67 index >20%). Ki-67 is a prognostic marker ( Foltyn et