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Stéphanie Larose Division of Endocrinology, Department of Medicine, Centre hospitalier de l’Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada

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Dany Rioux Division of Endocrinology, Department of Medicine, Centre hospitalier universitaire régional, Trois-Rivières, QC, Canada

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Roula Albadine Department of Pathology, Centre hospitalier de l’Université de Montréal, Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada, Montréal, QC, Canada

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André Lacroix Division of Endocrinology, Department of Medicine, Centre hospitalier de l’Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada

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. 2020 ). The most common are well-differentiated bronchial NETs and small-cell carcinomas ( Rekhtman 2022 ). We describe a rare case of EAS from a large-cell neuroendocrine carcinoma (LCNEC) ‘with morphologic features of carcinoid tumor’ of the lung

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Syed Ehsanullah Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Siteman Cancer Center, St Louis, Missouri, USA

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Nikolaos A Trikalinos Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Siteman Cancer Center, St Louis, Missouri, USA

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1), bronchial NETs ( Pelosi et al. 2010 ) (RASSF1A), as well as Merkel cell carcinomas ( Lassacher et al. 2008 ) (RASSF1A). Adrenocortical cancers are generally hypomethylated but there is literature in hypermethylation of CDKN2A and GATA4

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Joel George Hampshire Hospitals NHS Trust, Basingstoke, United Kingdom of Great Britain and Northern Ireland

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John Ramage Hampshire Hospitals NHS Trust, Basingstoke, United Kingdom of Great Britain and Northern Ireland

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Benjamin White Hampshire Hospitals NHS Trust, Basingstoke, United Kingdom of Great Britain and Northern Ireland

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Rajaventhan Srirajaskanthan Kings Health Partners NET Centre of Excellence, London, United Kingdom of Great Britain and Northern Ireland

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tumours (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). There are four grades for NENs: NET G1 (Ki-67 index <3%), NET G2 (Ki-67 index 3–20%), NET G3 (Ki-67 index >20%) and NEC (Ki-67 index >20%). Ki-67 is a prognostic marker ( Foltyn et

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