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Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy
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Introduction Adrenocorticotropic hormone (ACTH)-secreting pituitary neuroendocrine tumors (PitNETs) are the cause of Cushing’s disease (CD), a rare and potentially fatal systemic condition due to chronic exposure to cortisol, that results in
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Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
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Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
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(SSTR5), the main pharmacology targets of prolactin (PRL)-, growth hormone (GH)- and adrenocorticotropic hormone (ACTH)-secreting PitNETs, respectively. In this scenario, FLNA plays a pivotal role in determining the antitumoral action of dopaminergic and
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therapeutic response ( Table 1 ). Table 1 Classification of PitNETs. Family Tumor type Tumor subtype Transcription factor(s) Hormones Other biomarkers TPIT Corticotroph Densely granulated TPIT ACTH Keratins
Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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Faculty of Medicine, the University of Queensland, Brisbane, QLD, Australia
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Garvan Institute of Medical Research, Sydney, NSW, Australia
St Vincent’s Clinical School, University of New South Wales, Sydney, NSW, Australia
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sella region such as craniopharyngiomas or meningiomas. The authors have chosen not to discuss the proposed nomenclature change from ‘pituitary adenoma’ to ‘PitNET’, as described in the WHO 2022 classification, as this is the subject of significant
