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Molecular mechanisms involved in somatostatin receptor regulation in corticotroph tumors: the role of cytoskeleton and USP8 mutations

Erika Peverelli

Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Donatella Treppiedi

Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani

Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy

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ubiquitin-specific peptidase 8 (USP8) have been shown to regulate SSTR5 in corticotroph tumors, suggesting clinical implications in the pharmacological responsiveness to pasireotide treatment. Role of cytoskeleton protein FLNA FLNA is a large

Article Type:: Review Article

DOI:: https://doi.org/10.1530/EO-22-0042

Volume/Issue:: Volume 2: Issue 1

Open access

Pituitary carcinoma: reclassification and implications in the NET schema

Sylvia L Asa

Sylvia L Asa Department of Pathology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

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Shereen Ezzat

Shereen Ezzat Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada

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activating mutations of GNAS that result in constitutive activation of cyclic AMP signaling and some corticotroph tumors have mutations of the USP8 or USP48 genes ( Ezzat et al. 2018 , Asa et al. 2021 c ); occasional aggressive corticotroph

Article Type:: Review Article

DOI:: https://doi.org/10.1530/EO-22-0041

Volume/Issue:: Volume 2: Issue 1

Open access

Pituitary tumors and the risk of other malignancies: is the relationship coincidental or causal?

Sandra Pekic

Sandra Pekic School of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center Belgrade, Belgrade, Serbia

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Marko Stojanovic

Marko Stojanovic School of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center Belgrade, Belgrade, Serbia

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Vera Popovic

Vera Popovic School of Medicine, University of Belgrade, Belgrade, Serbia

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identified in 30% of somatotropinomas, GPR101 mutation identified in 4% of somatotropinomas and USP8 mutation identified in 40% of corticotrophinomas, are not clearly associated with tumor behavior ( Reincke et al. 2015 , Chen et al. 2018 , Sbiera