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Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Milan, Italy

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last years, some molecular factors playing a role in the modulation of SSTR5 expression and activity in ACTH-secreting PitNET cells have been identified. In particular, the cytoskeleton actin-binding protein filamin A (FLNA) and the mutational status of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EO-22-0042
Volume/Issue:
Volume 2: Issue 1
Open access
Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Rosa Catalano Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Federica Mangili Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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(SSTR5), the main pharmacology targets of prolactin (PRL)-, growth hormone (GH)- and adrenocorticotropic hormone (ACTH)-secreting PitNETs, respectively. In this scenario, FLNA plays a pivotal role in determining the antitumoral action of dopaminergic and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EO-22-0055
Volume/Issue:
Volume 2: Issue 1
Open access