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Nathan J Graham Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Joshua D Smith Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Tobias Else Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Gregory J Basura Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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synchronous PGLs, recommends lifelong surveillance, and is the basis for identifying other at-risk family members. Catecholamine-secreting HNPGLs Catecholamine-secreting HNPGLs are rare with sparse documentation of true incidence rates. This may

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Sofia Maria Lider Burciulescu CI Parhon National Institute of Endocrinology, Bucharest, Romania

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Caren Randon Department of Thoracic and Vascular Surgery, Ghent University Hospital & Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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Frederic Duprez Department of Radiotherapy-Oncology, Ghent University Hospital, Ghent Belgium & Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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Wouter Huvenne Department of Head and Neck Surgery, Ghent University Hospital & Department of Head & Skin, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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David Creytens Department of Pathology, Ghent University Hospital, Ghent University & Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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Kathleen B M Claes Center for Medical Genetics, Ghent University Hospital & Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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Robin de Putter Center for Medical Genetics, Ghent University Hospital & Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences, UGent, Ghent, Belgium

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Guy T’Sjoen Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine & Pediatrics, Faculty of Medicine and Health Sciences, UGent , Ghent, Belgium

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Corin Badiu CI Parhon National Institute of Endocrinology, Bucharest, Romania
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Bruno Lapauw Department of Endocrinology, Ghent University Hospital & Department of Internal Medicine & Pediatrics, Faculty of Medicine and Health Sciences, UGent , Ghent, Belgium

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, paragangliomas (PGL) can occur at various body sites and are traditionally divided into head-and-neck PGL (HNPGL) and PGL located in the thorax, abdomen, or pelvis. The incidence of PPGL is about 0.7 cases per 100,000 persons/year ( Leung et al. 2021 ). The

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Sunita M C De Sousa Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia
South Australian Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, Australia
Adelaide Medical School, University of Adelaide, Adelaide, Australia

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and Metabolism 104 523 – 538 . ( https://doi.org/10.1210/jc.2018-01071 ) Stiles CE Lloyd G Bhattacharyya S Steeds RP Boomla K Bestwick JP Drake WM 2021 Incidence of cabergoline-associated valvulopathy in primary care patients with prolactinoma using

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Donatella Treppiedi Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Rosa Catalano Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Federica Mangili Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Giovanna Mantovani Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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Erika Peverelli Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Endocrinology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy

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prognosis and an incidence between 0.7 and 2 cases per million each year ( Berruti et al. 2021 ). To date, the best curative options are complete tumor resection and treatment with mitotane ( Fassnacht et al. 2018 , Amodru et al. 2020 ). Insulin

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Erina Iwabuchi Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan

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Yasuhiro Miki Department of Disaster Obstetrics and Gynecology, International Research Institute of Disaster Science (IRIDes), Tohoku University, Sendai, Japan

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Takashi Suzuki Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, Sendai, Japan

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Hironobu Sasano Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan

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. Scientific Reports 7 1109. ( https://doi.org/10.1038/s41598-017-01187-4 ) Sung H Ferlay J Siegel RL Laversanne M Soerjomataram I Jemal A Bray F 2021 Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36

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Trinidad Raices Laboratory of Molecular Endocrinology and Signal Transduction, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
Centro de Investigaciones Endocrinológicas ’Dr. César Bergadá’ (CEDIE-CONICET-FEI), División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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María Luisa Varela Departments of Neurosurgery, and Cell and Developmental Biology, University of Michigan, School of Medicine, Ann Arbor, Michigan, USA

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Adriana María Belén Abiuso Laboratory of Molecular Endocrinology and Signal Transduction, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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Elba N Pereyra Laboratory of Molecular Endocrinology and Signal Transduction, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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Carolina Mondillo Laboratory of Molecular Endocrinology and Signal Transduction, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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Omar P Pignataro Laboratory of Molecular Endocrinology and Signal Transduction, Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina

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María Fernanda Riera Centro de Investigaciones Endocrinológicas ’Dr. César Bergadá’ (CEDIE-CONICET-FEI), División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina

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development of Leydig cell stromal tumours, which represent about 1–3% of testicular neoplasms in adults and 3% in children. They have two peaks of incidence: in the third to sixth decade in adults, and in children aged 3–9 years ( Albers et al. 2017

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Gido Snaterse Department of Endocrinology and Metabolism, Ghent University Hospital, Ghent, Belgium

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Johannes Hofland Section of Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

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Bruno Lapauw Department of Endocrinology and Metabolism, Ghent University Hospital, Ghent, Belgium

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and Cellular Endocrinology 377 135 – 146 . ( https://doi.org/10.1016/j.mce.2013.07.006 ) Sung H Ferlay J Siegel RL Laversanne M Soerjomataram I Jemal A & Bray F 2021 Global cancer statistics 2020: GLOBOCAN estimates of incidence and

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