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Sandra Pekic School of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center Belgrade, Belgrade, Serbia

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Marko Stojanovic School of Medicine, University of Belgrade, Belgrade, Serbia
Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center Belgrade, Belgrade, Serbia

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Vera Popovic School of Medicine, University of Belgrade, Belgrade, Serbia

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pituitary disease had previously undiagnosed pituitary tumors, incidentalomas and clinically relevant pituitary tumors ( Hall et al. 1994 , Burman & Saeger 2006 ). Epidemiological studies show an increased incidence and prevalence of pituitary tumors in

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Syed Ehsanullah Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Siteman Cancer Center, St Louis, Missouri, USA

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Nikolaos A Trikalinos Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Siteman Cancer Center, St Louis, Missouri, USA

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Background Pancreatic neuroendocrine neoplasms (PanNEN) can be challenging to treat, owing to their rarity and heterogeneity. Their incidence and prevalence have increased in the last few decades and so has, thankfully, our understanding of

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D Mc Donald Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland

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M Sherlock Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland

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C J Thompson Academic Department of Endocrinology, Beaumont Hospital, Dublin, Ireland

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prevalence of hyponatraemia in lung cancer was 25%; however, the findings were highly discordant, ranging from 3 to 95% due to heterogeneity in patient characteristics, evaluation of hyponatraemia and the cut-off points used ( Bartalis et al. 2021

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José V Lima Jr Department of Medicine, Division of Endocrinology and Metabolism, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil
Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, Brazil
Fleury Group, São Paulo, SP, Brazil

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Nilza M Scalissi Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, Brazil

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Kelly C de Oliveira Department of Medicine, Division of Endocrinology and Metabolism, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil

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Susan C Lindsey Department of Medicine, Division of Endocrinology and Metabolism, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil

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Caroline Olivati Fleury Group, São Paulo, SP, Brazil

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Elisa Napolitano Ferreira Fleury Group, São Paulo, SP, Brazil

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Claudio E Kater Department of Medicine, Division of Endocrinology and Metabolism, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil

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also possible that the prevalence of RET gene PV in the Brazilian population is actually higher, as was also observed with the control sample from the Fleury Group databases, which encompasses patients from the four major regions of Brazil. Some

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Lucinda M Gruber Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA

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Steven N Hart Department of Computational Pathology and Artificial Intelligence, Mayo Clinic, Rochester, Minnesota, USA

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Louis James Maher III Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA

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truncating variant prevalence being slightly lower (5.6%). Missense variants We sought to predict the biochemical severities of unique SDH missense variants and the distribution of these predicted biochemical severities among SDH subunits. For this

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Nathan J Graham Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Joshua D Smith Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Tobias Else Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA

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Gregory J Basura Department of Otolaryngology – Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

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(SRS) may be indicated ( Netterville et al. 1998 ). GJ diagnosis is typically delayed due to its low prevalence, difficult-to-examine location, and slow growth rate ( Carlson et al. 2015 ). Once diagnosed, symptoms have often been present for

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Anna Stroud Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
St Vincent’s Hospital Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia
Garvan Institute of Medical Research, Sydney, Australia

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Pearl Dhaliwal Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
St Vincent’s Hospital Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia
Garvan Institute of Medical Research, Sydney, Australia

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Richard J Harvey Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia

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Raquel Alvarado Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia

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Benjamin P Jonker Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
Faculty of Medicine, Notre Dame University, Sydney, Australia
Institute of Academic Surgery, Royal Prince Alfred Hospital, Sydney, Australia

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Mark J Winder Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
St Vincent’s Hospital Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia
Faculty of Medicine, Notre Dame University, Sydney, Australia

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Jessica W Grayson Rhinology and Skull Base Research Group, St Vincent’s Centre for Applied Medical Research, Sydney, Australia
Department of Otolaryngology Head and Neck Surgery, University of Alabama Birmingham, Birmingham, Alabama, USA

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Ann McCormack St Vincent’s Hospital Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia
Garvan Institute of Medical Research, Sydney, Australia
Department of Endocrinology, St Vincent’s Hospital, Sydney, Australia

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occurred in two patients undergoing revision surgery. Table 4 Complications related to transsphenoidal surgery for Cushing’s disease Complication Prevalence Primary surgery Revision surgery P value Number undergoing

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Jose E Nunez Division of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Sylvia Ng Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Hanbo Chen Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Simron Singh Division of Medical Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Julie Hallet Department of Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Calvin Law Department of Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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Sten Myrehaug Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada

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D Zhao B Zhou S Xu Y Shih T & Yao JC 2017 Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States . JAMA Oncology 3 1335 – 1342 . ( https://doi.org/10.1001/jamaoncol.2017

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Mark S Stein Knox Private Hospital, Wantirna, Victoria, Australia

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Victor Kalff Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence (ProsTIC), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Scott G Williams Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Declan G Murphy Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Peter G Colman Department of Diabetes and Endocrinology, The Royal Melbourne Hospital and University of Melbourne Department of Medicine, Parkville, Victoria, Australia

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Michael S Hofman Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence (ProsTIC), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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expression. This small number of participants is a significant limitation of our study and does not enable us to determine the prevalence of such expression, as detected by exendin PET/CT, at this very late stage of prostate cancer. In a small sample size

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Vineeth Sukrithan Division of Medical Oncology, Department of Internal Medicine, The Ohio State University and Arthur G James Cancer Center, Columbus, Ohio, USA

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Prachi Jain Division of Medical Oncology, Department of Internal Medicine, The Ohio State University and Arthur G James Cancer Center, Columbus, Ohio, USA

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Manisha H Shah Division of Medical Oncology, Department of Internal Medicine, The Ohio State University and Arthur G James Cancer Center, Columbus, Ohio, USA

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Bhavana Konda Division of Medical Oncology, Department of Internal Medicine, The Ohio State University and Arthur G James Cancer Center, Columbus, Ohio, USA

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fusion oncogenes ( Nikiforova et al. 2003 , Elisei et al. 2008 , Howell et al. 2013 ). Poorly differentiated thyroid cancer Compared to DTC, there is an increased prevalence of TERT promotor mutations (33–40%), EIF1AX mutations (10

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