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  • Author: Diego Enrico x
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Marcos Daniel Bortz M Bortz, Medical Oncology, Alexander Fleming Institute, Buenos Aires, C1426ANZ, Argentina

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Andres Rodriguez A Rodriguez, medical oncolgy, Instituto Alexander Fleming, Buenos Aires, Argentina

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Maria Romina Luca M Luca, medical oncology, Instituto Alexander Fleming, Buenos Aires, Argentina

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Federico Waisberg F Waisberg, Instituto Alexander Fleming, Buenos Aires, Argentina

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Diego Enrico D Enrico, medical oncology, Instituto Alexander Fleming, Buenos Aires, Argentina

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Berenice Freile B Freile, Instituto Alexander Fleming, Buenos Aires, Argentina

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Greta Catani G Catani, Instituto Alexander Fleming, Buenos Aires, Argentina

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Federico Esteso F Esteso, medical oncology, Instituto Alexander Fleming, Buenos Aires, Argentina

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Marina Musumeci M Musumeci, Nuclear Medicine, Instituto Alexander Fleming, Buenos Aires, Argentina

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Eliana Vazquez E Vazquez, nuclear medicine, Instituto Alexander Fleming, Buenos Aires, Argentina

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Matias Chacón M Chacón, Medical Oncology, Instituto Alexander Fleming, Buenos Aires, Argentina

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Juan Manuel Manuel OConnor J OConnor, Alexander Fleming Institute, Buenos Aires, C1426ANZ, Argentina

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Silvina Racioppi S Racioppi, Nuclear medicine, Instituto Alexander Fleming, Buenos Aires, Argentina

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Objectives: We aim to investigate the time toxicity of patients with gastroenteropancreatic-neuroendocrine tumours treated with lutetium-177 Dotatate in a single institution.

Design: This is a retrospective cohort study.

Methods: All patients with gastroenteropancreatic-neuroendocrine tumours treated with lutetium-177 Dotatate in the Alexander Fleming Institute were included. Our primary endpoint was to evaluate time toxicity, which accounted for every day that the patient had contact with any department of any healthcare institution.

Results: Our cohort included 21 patients with metastatic disease, female sex 86%, and had a median age of 55 (IQR 44-63). The primary tumour site was small intestine in 47.6% of the cases. The median number of previous systemic treatments for advanced disease was 2 (IQR 2 - 3). The overall response rate was 19%, and 66.6% had disease clinical benefit. The median calculated 'time toxicity' was 11 days (IQR 8-18), representing 5.7% of the total treatment duration. The main contributors to time-toxicity included infusion days, blood draws, radiological scans, and hospitalizations (median 4 days for each).

Conclusion: Lutetium-177 Dotatate treatment for gastroenteropancreatic-neuroendocrine tumours was associated with a low time toxicity, excellent tolerability, good response and a prolonged PFS, of which the median was not reached in the short follow-up we present. Newer treatments with different mechanisms of action provide longer survivals and widen the landscape of choices. Understanding new clinical endpoints is important for the transition into a more modern clinical practice, strengthening personalised and patient-oriented strategies.

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